How to Run AI Agents on DGX Spark & DGX Station

Published on
March 17, 2026
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Artificial intelligence is entering a new phase. Early AI tools focused on answering prompts or generating text on demand. New systems now behave more like autonomous software agents that plan tasks, call tools, analyze data, and operate continuously. These agents often run workflows such as research automation, code generation, internal knowledge search, or data monitoring.

This shift creates new infrastructure requirements. Traditional cloud environments were designed for burst workloads that start and stop when needed. Agent systems behave differently. They remain active for long periods, store memory between tasks, and access private company data.

New hardware platforms now make it possible to run these systems locally. The DGX Station, developed by NVIDIA, is a desktop supercomputer capable of running extremely large AI models without relying entirely on the cloud. With large unified memory and high compute throughput, developers can build and operate advanced AI workloads directly from their own infrastructure.

This change matters for teams building AI agents. Instead of sending sensitive data to remote servers, organizations can run models, tools, and automation pipelines locally. Platforms such as Knolli allow teams to coordinate these agents, connect them with internal data sources, and automate workflows while the underlying hardware provides the computing power needed to run large models.

Together, local AI infrastructure and agent orchestration platforms are reshaping how AI systems are built, tested, and deployed.

What Is NVIDIA DGX Station?

The DGX Station is a high-performance AI workstation designed to run large models and advanced AI workloads locally. Built by NVIDIA, it delivers data-center-level computing power in a system that fits beside a developer’s desk.

Unlike typical workstations, DGX Station is built specifically for artificial intelligence training, inference, and agent development. It combines powerful GPU acceleration, large unified memory, and specialized AI software to support extremely large neural networks.

The latest DGX Station model is built around the GB300 Grace Blackwell Ultra Desktop Superchip, which combines a high-core-count Grace CPU with a Blackwell GPU. These processors communicate through NVIDIA’s NVLink-C2C interconnect, allowing the CPU and GPU to share memory at extremely high bandwidth. This architecture removes the traditional bottleneck that occurs when data moves between separate CPU and GPU memory pools.

The system delivers 20 petaflops of AI computing performance, meaning it can perform about 20 quadrillion operations per second. Less than a decade ago, this level of computing power existed only in large research supercomputers. The DGX Station brings a meaningful portion of that capability into a desktop environment.

Memory capacity is another defining feature. The workstation includes 748 GB of unified memory, which is essential for running large AI models. Modern neural networks must be fully loaded into memory during inference. If the memory capacity is too small, the model cannot run regardless of how powerful the processor is. With hundreds of gigabytes of coherent memory, the DGX Station can support extremely large language models and other advanced AI systems.

For developers building AI agents or experimenting with large models, this architecture provides a local environment in which models, tools, and workflows can run continuously without relying entirely on remote infrastructure.

Why AI Agents Need Always-On Hardware

AI systems are moving beyond simple prompt-based tools. Modern applications increasingly rely on autonomous AI agents that can reason through tasks, call external tools, write code, analyze documents, and execute workflows without constant human input.

Unlike chat-based models that activate only when a prompt arrives, these agents operate continuously. They maintain state, track progress, and respond to changing conditions in real time. Because of this behavior, agent systems depend on infrastructure that remains active at all times.

Always-on agents require three main resources:

  • Persistent computing so models can process tasks continuously
  • Persistent memory so agents remember context, history, and decisions
  • Persistent runtime environments where tools, APIs, and workflows stay active

Traditional cloud GPU instances often spin up and shut down based on demand. This model works well for training jobs or batch inference tasks. It becomes less efficient for systems that must operate around the clock.

Local AI infrastructure provides a better environment for these workloads. A machine like the DGX Station can run models and agents continuously without interruptions. Developers can keep models loaded in memory, maintain persistent databases, and run long-running processes that manage complex workflows.

This architecture also helps when agents interact with internal company systems. Many agent workflows require access to sensitive data sources such as:

  • Private documents
  • Internal databases
  • Enterprise software tools
  • Proprietary research datasets

Running these systems locally reduces security risks because data remains within the organization’s infrastructure instead of being transmitted to external cloud environments.

As AI shifts toward agent-based systems that operate continuously, infrastructure designed for persistent workloads becomes increasingly important. Always-on hardware enables agents to run reliably, maintain context, and complete complex tasks over long periods without interruption.

Benefits of Running AI Agents Locally

Running AI agents on local infrastructure gives teams more control over their models, data, and workflows. While cloud platforms remain useful for large-scale training or burst workloads, many organizations now prefer to run certain AI systems closer to their internal data.

Hardware such as the DGX Station allows developers to run large models and autonomous agents without depending entirely on external infrastructure. This approach introduces several practical advantages for companies building AI-driven tools and automation.

Data Privacy and Security

Many AI workflows rely on sensitive information such as internal documents, research data, financial records, or proprietary code. Sending this data to external cloud services introduces security and compliance concerns.

Running AI agents locally allows organizations to keep data within their own infrastructure. Models can process internal files, connect to private databases, and operate inside secured environments where information never leaves the organization.

This setup is especially valuable in industries such as healthcare, finance, research, and government, where strict data policies apply.

Lower Latency

Local infrastructure reduces the time required for models to access data and tools. When agents interact with internal systems, each request to a remote cloud service incurs network delay.

Running agents on nearby hardware allows them to process tasks faster. Data retrieval, tool execution, and model inference occur within the same environment rather than traversing external networks.

This improvement becomes important for agents that execute multiple steps or interact with several systems during a workflow.

Cost Control for Continuous Workloads

Cloud GPU infrastructure is designed for flexible scaling. That flexibility comes with ongoing operational costs that grow as workloads run longer.

Autonomous agents often operate continuously, which means inference costs can accumulate quickly in cloud environments. Running persistent workloads on local hardware provides predictable infrastructure costs because the system operates on owned resources rather than rented compute.

Full Infrastructure Control

Local AI systems give teams direct control over the environment where agents operate. Developers can choose models, manage memory allocation, configure networking policies, and integrate custom tools without being restricted by the cloud platform.

This flexibility allows organizations to design AI systems that match their internal processes. They can experiment with different model architectures, run custom agent workflows, and connect AI tools to existing software stacks.

Support for Air-Gapped Environments

Some organizations must operate in environments where systems cannot connect to external networks. These air-gapped setups appear in defense, regulated research labs, and critical infrastructure operations.

Local AI hardware enables the execution of large models and intelligent agents in these isolated environments. Because the entire AI stack operates inside the organization’s infrastructure, the system remains compliant with strict security requirements.

Local AI infrastructure does not replace the cloud entirely. Many organizations still rely on cloud systems for large-scale training and distributed computing. Instead, the industry is moving toward a hybrid model in which developers build and test AI systems locally and scale them as needed.

In that model, local hardware becomes the foundation for building and operating intelligent agents that interact directly with private data and internal tools.

What Is DGX Spark?

While the DGX Station targets large AI workloads and trillion-parameter models, DGX Spark is designed for smaller teams and development environments that still need serious GPU power.

DGX Spark acts as a compact AI development system that can run advanced models, support experimentation, and help teams prototype AI applications locally. It provides a practical entry point for organizations that want local AI infrastructure without having to invest in a full workstation-scale system.

The platform focuses on flexibility and scalability. Individual Spark units can operate independently for model testing, agent development, or inference workloads. For teams that need more power, multiple units can be connected together.

NVIDIA expanded the system to support clustering, allowing up to four DGX Spark devices to operate as a single unified environment. When connected this way, the systems scale performance close to linearly, creating a small AI compute cluster that can sit on a conference table rather than inside a server rack.

This configuration works well for teams that want to build and test AI systems locally before scaling them further.

Common use cases for DGX Spark

Smaller AI infrastructure platforms such as DGX Spark are useful for many development scenarios:

  • Model experimentation for mid-size language models
  • Agent development environments where teams test workflows and tools
  • Fine-tuning open models using internal company datasets
  • Departmental AI infrastructure for research groups or data science teams
  • Prototype environments before scaling applications to larger compute systems

For organizations building AI agents, DGX Spark provides a development layer where teams can experiment with models, automation pipelines, and agent behaviors before deploying them on larger infrastructure.

Together, DGX Spark and DGX Station form a layered AI development environment. Smaller systems support experimentation and testing, while larger workstations provide the computing power required to run advanced models and continuous agent workloads.

From Local Development to Data Center Scale

One of the most practical ideas behind the DGX Station ecosystem is what NVIDIA calls architectural continuity. This means software built on a local workstation can scale to large GPU clusters without major engineering changes.

In many AI projects today, moving from development to production introduces significant friction. Developers might train or test models on local machines, then rewrite parts of the system to run on cloud infrastructure with different hardware, networking, or memory configurations. That process slows down experimentation and increases engineering effort.

NVIDIA designed the DGX platform to reduce this problem. Systems across the stack run the same AI software environment, allowing applications developed locally to move directly to larger compute environments when additional capacity is required.

Typical AI development workflow

Teams building AI systems often follow a progression like this:

  • Prototype locally: Developers build models, tools, and agent workflows on a workstation.
  • Test and refine applications: Teams experiment with prompts, workflows, and data pipelines while monitoring performance.
  • Scale to larger infrastructure: When workloads grow, the same applications can run on larger GPU clusters or data center systems.

Because the underlying architecture remains consistent, developers do not need to redesign the entire system when scaling.

Why this matters for AI agent systems

Agent-based applications involve several moving parts. A typical system might include:

  • Large language models
  • Memory stores
  • Workflow automation
  • Tool integrations
  • Internal APIs and databases

Moving these components between different infrastructure environments can become complicated if the hardware stack changes significantly.

By keeping the development and production environments compatible, the DGX ecosystem allows teams to build and refine AI agents locally before deploying them on a larger scale.

For organizations experimenting with AI automation, this continuity shortens development cycles and makes it easier to move from early prototypes to full production systems without extensive infrastructure changes.

Running AI Agents on DGX Infrastructure

Hardware like the DGX Station and DGX Spark provides the computing power required to run modern AI models. To build useful AI applications, teams still need a software layer that coordinates models, tools, and workflows.

AI agents operate as systems made up of several interconnected components. These components allow the agent to interpret tasks, plan actions, and interact with external systems.

Core components of an AI agent system

Most agent architectures include the following elements:

  • Large Language Model (LLM): The model handles reasoning, language understanding, and decision making.
  • Tools and APIs: Agents connect to external tools such as search systems, databases, internal APIs, or code execution environments.
  • Memory systems: Agents store conversation history, prior actions, and contextual information to maintain long-running workflows.
  • Task planning logic: Agents break complex tasks into smaller steps and decide which tools or actions to execute.
  • Workflow orchestration: A system manages how multiple agents or processes interact during complex tasks.

Running these components locally allows organizations to build more powerful automation systems. Instead of relying entirely on cloud infrastructure, agents can access internal datasets, private APIs, and proprietary software directly.

Example AI agent workflow on DGX hardware

A typical agent workflow running on local infrastructure might look like this:

  • A user or system assigns a task to the agent.
  • The agent analyzes the request using a language model.
  • The agent selects the tools or APIs required to complete the task.
  • Data is retrieved from internal sources such as documents or databases.
  • The model processes the information and generates a result.

The system stores the output and updates memory for future tasks.

Because the model and data remain within the same infrastructure environment, the system can operate faster and with stronger security controls.

This type of architecture is particularly useful for teams building internal automation systems, research assistants, coding copilots, and analytics agents.

How to Run AI Agents on DGX Spark

The DGX Spark provides a compact environment for building and testing AI agents locally. While it is smaller than the DGX Station, it still offers enough GPU power to run mid-size language models, fine-tune open models, and develop multi-step agent workflows.

Running agents on DGX Spark typically involves installing the model runtime, loading an AI model, and connecting it to an orchestration layer that manages tools and workflows.

1. Prepare the DGX Spark Environment

Before deploying agents, developers configure the AI environment on the system.

Common setup steps include:

  • Install the NVIDIA AI software stack
  • Install CUDA and GPU drivers
  • Configure container environments such as Docker
  • Install Python AI frameworks used for agent development

Most teams use containerized environments so models and dependencies remain isolated and reproducible.

2. Install and Load AI Models

Agents rely on language models or multimodal models to interpret instructions and generate actions.

DGX Spark can run several open models commonly used for agent development, including:

  • Gemma models
  • Qwen models
  • Mistral models
  • DeepSeek models
  • Nemotron models

The model is loaded into GPU memory to perform inference tasks such as reasoning, tool selection, and content generation.

3. Configure the Agent Runtime

Once the model is available, developers install an agent runtime that enables the system to perform tasks autonomously.

An agent runtime usually provides:

  • prompt templates and reasoning logic
  • tool execution frameworks
  • memory management
  • task planning modules

These components allow the model to break down tasks and interact with external tools.

4. Connect Tools and Data Sources

AI agents become useful when they interact with external systems.

Typical integrations include:

  • internal databases
  • document storage systems
  • APIs and web services
  • code execution environments
  • analytics tools

Because DGX Spark runs locally, agents can securely connect to internal data sources without sending information to external cloud services.

5. Run Agent Workflows

After the model and tools are connected, the agent system can begin executing workflows.

For example, an internal research agent might:

  • Receive a research request
  • search internal documents
  • summarize relevant information
  • generate a report
  • store results in a knowledge system

DGX Spark provides the compute resources required for these workflows while allowing teams to experiment with agent behavior before scaling to larger infrastructure.

How to Run AI Agents on DGX Station

The DGX Station is designed for heavier workloads than DGX Spark. Its large unified memory and high compute throughput allow developers to run very large models and persistent agent systems directly from local infrastructure.

Running agents on DGX Station follows a similar process, but the system supports much larger models and more complex multi-agent environments.

1. Set Up the AI Infrastructure

Developers first configure the workstation with the NVIDIA AI stack.

This environment usually includes:

  • CUDA drivers and GPU libraries
  • container runtime for model deployment
  • AI frameworks for inference and fine-tuning
  • orchestration platforms for managing agents

Because the workstation includes a large unified memory, models can be loaded directly without splitting them across multiple devices.

2. Deploy Large Language Models

DGX Station supports large models that smaller systems cannot easily run.

Examples include:

  • large open-source language models above 100B parameters
  • multimodal models for vision and language
  • reasoning models used for autonomous agents

The workstation’s unified memory architecture keeps these models fully loaded, improving inference speed and stability for continuous workloads.

3. Configure Persistent Agent Systems

One major advantage of DGX Station is the ability to run agents continuously.

Developers can create systems where agents remain active 24/7 and manage complex workflows such as:

  • automated research pipelines
  • coding assistants for development teams
  • internal knowledge copilots
  • monitoring agents for data analytics

Persistent systems require long-running runtimes, memory storage, and task orchestration layers.

4. Run Multi-Agent Workflows

DGX Station can support multiple agents running simultaneously.

A multi-agent architecture might include:

  • a research agent gathering information
  • a planning agent organizing tasks
  • a coding agent executing technical steps
  • a reporting agent summarizing results

Because the system provides high compute capacity, several agents can run concurrently without resource constraints.

5. Connect Internal Enterprise Systems

Local AI infrastructure becomes particularly valuable when agents interact with internal company tools.

On DGX Station, agents can safely access:

  • proprietary documents
  • enterprise software systems
  • internal APIs
  • analytics databases

These integrations allow organizations to build AI systems that automate internal workflows while keeping sensitive information inside their infrastructure.

How Knolli Helps Run AI Agents on DGX

Running AI agents on systems such as DGX Station and DGX Spark provides the raw computing power required for large models. To build reliable AI applications, teams also need a platform that organizes models, tools, workflows, and data sources.

This is where Knolli becomes useful. Knolli serves as the orchestration layer connecting AI models running on DGX hardware to business workflows, internal data, and automated processes.

Instead of manually managing agent infrastructure, developers can use Knolli to design structured agent workflows that run on local GPU systems.

Build Custom AI Agents

Knolli allows teams to create specialized AI agents designed for different tasks. These agents can use large language models running on DGX hardware and interact with tools and APIs via the Knolli platform.

For example, teams can build:

  • research agents that analyze internal reports
  • coding agents that write and review software
  • knowledge agents that answer questions using company documents
  • analytics agents that monitor metrics and generate summaries

Each agent can be configured with its own prompts, tools, and workflows.

Connect Agents to Internal Data

Many AI systems are only useful when they can access company data. Knolli allows agents to connect to internal knowledge bases, APIs, and document systems.

These connections allow AI models running locally to work with:

  • company documents
  • databases
  • CRM systems
  • analytics dashboards
  • internal APIs

Because the infrastructure runs on DGX hardware, sensitive data remains inside the organization’s environment.

Manage Multi-Agent Workflows

Complex automation tasks often require multiple agents working together. One agent may gather data, another may analyze it, and another may generate a report.

Knolli provides a workflow layer in which developers can define how different agents interact. This makes it possible to run structured multi-agent systems that automatically complete complex tasks.

Operate Agents on Local Infrastructure

Knolli can run agent workflows on local AI infrastructure powered by DGX systems. The models run on GPU hardware, while Knolli coordinates task execution, tool usage, and workflow automation.

This setup allows organizations to build private AI systems that operate continuously without relying entirely on cloud infrastructure.

The Future of AI: Cloud + Local Infrastructure

Artificial intelligence infrastructure is moving toward a hybrid model. Instead of relying entirely on remote servers or completely local systems, many organizations are combining both approaches. Cloud platforms remain important for large-scale training and distributed workloads, while local infrastructure provides a stable environment for development, experimentation, and continuous AI operations.

Hardware such as the DGX Station enables running advanced models and autonomous agents directly within an organization’s infrastructure. This allows teams to prototype applications, fine-tune models with private data, and run internal AI systems without depending fully on cloud resources.

Cloud platforms still play a major role in the AI ecosystem. Large-scale model training, global applications, and massive inference workloads often require the elasticity of cloud GPU clusters. These environments allow organizations to scale workloads quickly without purchasing new hardware.

Because of this, the future of AI development is likely to follow a cloud-and-local workflow.

A typical hybrid AI workflow

Many teams already follow a pattern that combines both environments:

  • Develop and prototype locally: Developers build agent workflows, experiment with models, and test integrations on local systems.
  • Fine-tune models with internal data: Organizations run sensitive training jobs locally, keeping proprietary datasets private.
  • Deploy internal AI agents locally: Autonomous agents that interact with internal systems operate on local infrastructure.
  • Scale large workloads to the cloud: High-volume inference or large-scale training can be moved to cloud clusters as needed.

This approach provides flexibility. Teams gain the security and performance benefits of local AI infrastructure while still using the cloud when large-scale compute becomes necessary.

Why hybrid AI infrastructure is growing

Several trends are driving the move toward hybrid AI environments:

  • Data privacy requirements are increasing across industries.
  • Agent-based systems need a persistent infrastructure that runs continuously.
  • Large models require powerful local hardware with unified memory architectures.
  • Organizations want greater control over AI infrastructure and costs.

As a result, local systems are becoming an important layer in the AI stack rather than a replacement for the cloud.

Machines like DGX workstations bring supercomputer-level performance into development environments. Combined with cloud infrastructure, they allow teams to build AI systems that move smoothly from experimentation to production.

The result is a more balanced architecture where AI workloads run in the environment that best fits the task. Cloud platforms provide scale, while local infrastructure provides control, privacy, and persistent computing power for advanced AI applications.

Conclusion

Artificial intelligence is entering a stage where infrastructure matters as much as models. The rise of autonomous agents, large language models, and continuous AI workflows is pushing organizations to rethink where their systems run and how they are managed.

Hardware platforms such as the DGX Station and DGX Spark show that powerful AI computing is no longer limited to massive data centers. Developers and teams can now run advanced models locally, build agent workflows, and operate AI systems directly inside their own infrastructure.

Local AI hardware brings several advantages. Teams can maintain control over sensitive data, reduce latency when agents interact with internal systems, and run continuous workloads without depending entirely on external cloud environments. At the same time, cloud infrastructure remains valuable for large-scale training and high-volume workloads.

Because of this, the future of AI development is likely to combine both environments. Organizations will prototype locally, run internal agents on private infrastructure, and scale workloads to the cloud when necessary.

As AI continues to evolve toward agent-driven systems that reason, plan, and automate tasks, access to powerful local infrastructure will become increasingly important. Systems that once required large research facilities are now accessible to individual developers and small teams, making advanced AI development far more practical and widely available.

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Frequently Asked Questions

Can AI agents run locally without cloud infrastructure?

Yes. AI agents can run locally if the system has enough computing power and memory to load the required models. Hardware platforms like the DGX Station provide large unified memory and high GPU performance, which makes it possible to run advanced language models and agent systems directly on local machines.

Running agents locally allows organizations to keep sensitive data inside their infrastructure while maintaining full control over models and workflows.

What is the difference between DGX Station and DGX Spark?

Both systems are designed for AI development, but they serve different purposes.

The DGX Station is a high-performance AI workstation capable of running extremely large models and advanced workloads. It includes a large unified memory and a powerful GPU compute designed for serious AI research and development.

The DGX Spark is a smaller system intended for teams that need a compact AI development environment. Multiple Spark units can also be clustered together to create a small local AI compute system.

Can small teams build AI systems using DGX hardware?

Yes. Systems such as DGX Spark are designed for smaller teams and research groups. These systems allow developers to experiment with models, fine-tune AI systems, and build agent workflows locally before scaling workloads to larger infrastructure.

This makes advanced AI development accessible to organizations that previously depended entirely on cloud GPU services.